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Use with MOA inhibitors and Serotonin Reuptake Inhibitors.
Carbamazepine: Concomitant use with carbamazepine may cause a significant increase in tramadol metabolism.
Quinidine: Concomitant use with quinidine with tramadol results in an increase in the concentration of tramadol.
Substances that similar to warfarin: close examination of prothrombin time must be carried out in co-administration with warfarin-like compounds, because there are reports of an increase in INR in some patients.
Inhibitor CYP2D6: In vitro studies shows that concomitant use with CYP2D6 inhibitors such as fluoxetine, paroxetine and amitriptyline may cause inhibition in tramadol metabolism.
